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Parvinder Kaur at al. (2025) Challenges in the interpretation of DNT endpoints and their regulatory implications
Developmental neurotoxicity (DNT) studies are designed to provide information on potential functional, behavioural and morphological effects on the developing nervous system after in utero and early-life exposure to chemical compounds. The current in vivo testing paradigm for DNT includes OECD TG 426, US EPA OPPTS 870.6300 and OECD TG 443 with the inclusion of DNT cohorts.
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Michail Gioutlakis et. al. (2025) Benchmark Dose Modelling in human tox and environmental risk assessment
Benchmark Dose (BMD) Modelling is an approach used to derive toxicological endpoints for environmental (ERA) and human risk assessment. The aim of a BMD approach is to determine a dose-level that triggers a measurable change in a relevant toxicological parameter following exposure to a chemical, i.e. the Benchmark Response (BMR).
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Hanisch et al. (2025) Precise pesticide application - an earthworm field study
In the course of the advancing digitalization of agriculture, the precision application of pesticides is coming more and more into focus. Today’s technology enables farmers to apply products only on spots or areas where needed. This leads to more heterogeneous pesticide spraying patterns compared with conventional full-area application.
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1 MB
The Festival of the Snakes of Cocullo
Where is the connection between RIFCON, snakes, the Italian village Cocullo, between The New York Times, The Guardian and magazines such as Nature or Stern? …Does this pique your interest? Take a look here!
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Wittwer at al. (2024) After dark, all CATs are leopards
Recently, the ‘Closure Principle Computational Approach Test’ (CPCAT) was developed as a method that should overcome the shortcomings of NOEC/LOEC application in ecotoxicological pesticide risk assessments. CPCAT is supposed to handle abundance data characterized by low abundances, Poisson distributed, and overdispersion without restrictions.
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528 KB
Kunz et al. (2024) Extraction Efficiency for Food and Feed
Extraction methods can vary greatly in their efficiency to extract so-called incurred residues that form when plant protection products are applied to agricultural crops. Active substances and their metabolites can be incorporated into food or feed crops, and thus may occur in tissues and animal products.
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218 KB
Laucht et al. (2024) Ornamental Phoenix palm trees as habitat for fauna in the Mediterranean Region – results from a full year monitoring
In the European Mediterranean Region, palm trees are a common element in cities and semi-urban landscapes and have become important habitat structures for local fauna. This study aimed to monitor the invertebrate and vertebrate fauna occurring on and associated with ornamental palms of the genus Phoenix, over the course of one year.
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528 KB
Singer at al. (2023) BEEHAVE – Analysing the Significance of Increased Brood Termination Rate on the Colony Strength in Honey Bees
The brood termination rate (BTR) investigated in higher-tier studies according to OECD GD 75 for pesticide risk assessment is the determinant of honey bee (Apis mellifera) mortality during pre-imaginal development and thus influences colony strength.
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1 MB
Jakoby at al. (2023) Spatially explicit population models support impact assessment of precision application - a common vole example
Precision farming has the potential to reduce the impact of pesticides on the environment. Particularly, a more precise use of pesticides can result not only in a reduced pesticide load, but also in a spatially heterogeneous application pattern on the field scale. Accordingly, the effect of the pesticide on populations of non-target species might change.
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2 MB
Jakoby at al. (2022) A user-friendly software tool for DEB-TKTD model predictions
Toxicokinetic-toxicodynamic models based on dynamic energy budget theory (DEB-TKTD models) simulate sublethal effects of pesticides, exploring the effects of toxicants on growth and reproduction over time.
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714 KB
Bauer et al. (2023) A Toxicokinetic–Toxicodynamic Modeling Workflow Assessing the Quality of Input Mortality Data
Toxicokinetic–toxicodynamic (TKTD) models simulate organismal uptake and elimination of a substance (TK) and its effects on the organism (TD). The Reduced General Unified Threshold model of Survival (GUTS‐RED) is a TKTD modeling framework that is well established for aquatic risk assessment to simulate effects on survival.
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1 MB
Faupel et al. (2023) Precision farming and environmental pesticide regulation in the EU—How does it fit together?
Precision farming technology allows pesticides to be applied precisely to the target while leaving the rest of the field untreated. In the regulation of pesticides, however, a homogeneously sprayed field is considered as the standard scenario.
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113 KB